Watch Intently (one)trofinetide will raise the degree or result of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.lorlatinib will lessen the extent or result of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Avoid use of lorlatinib with CYP3A substrates, the place ne